Onaka T, Yagi K
Department of Physiology, Jichi Medical School, Tochigi-ken, Japan.
Neurosci Lett. 1990 Dec 11;120(2):187-90. doi: 10.1016/0304-3940(90)90034-7.
Interactions between emotional stress due to fear and hypovolemic stimuli on vasopressin secretion were studied in rats. Intraperitoneally injected dextran did not significantly change plasma osmolality and arterial blood pressure but increased blood hemoglobin and plasma vasopressin level. An i.v. infused physiological solution reversed these changes. Emotional stress due to fear acquired by learning suppressed plasma vasopressin level in dextran-injected rats. Emotional stress due to fear produced by low-frequency footshocks also suppressed the increased plasma vasopressin level. These results suggest that emotional stress due to fear interacts with afferent neural signals originating from cardio-vascular volume receptors in the control of vasopressin secretion.
在大鼠中研究了恐惧引起的情绪应激与低血容量刺激对血管加压素分泌的相互作用。腹腔注射右旋糖酐不会显著改变血浆渗透压和动脉血压，但会增加血红蛋白和血浆血管加压素水平。静脉输注生理溶液可逆转这些变化。通过学习获得的恐惧引起的情绪应激会抑制右旋糖酐注射大鼠的血浆血管加压素水平。低频足部电击产生的恐惧引起的情绪应激也会抑制血浆血管加压素水平的升高。这些结果表明，恐惧引起的情绪应激在血管加压素分泌的控制中与源自心血管容量感受器的传入神经信号相互作用。
