与双克隆冷自身凝集素相关的免疫性溶血性贫血。

Immune hemolytic anemia associated with biclonal cold autoagglutinins.

作者信息

Tschirhart D L, Kunkel L, Shulman I A

机构信息

Los Angeles County, University of Southern California Medical Center.

出版信息

Vox Sang. 1990;59(4):222-6. doi: 10.1111/j.1423-0410.1990.tb00241.x.

DOI:10.1111/j.1423-0410.1990.tb00241.x

PMID:1705735

Abstract

A 65-year-old man with bladder outlet obstruction due to prostatic hypertrophy was incidentally discovered to have cold-antibody autoimmune hemolytic anemia (cold-aggluthinin syndrome; CAS) due to autoanti-I (titer 1,024 at 4 degrees C and 64 at 30 degrees C), and a biclonal gammopathy. Immunofixation electrophoresis of serum and a red blood cell eluate revealed the patient's autoantibody to be biclonal IgM kappa and IgA kappa. No underlying cause could be determined to explain the development of either the biclonal gammopathy or the CAS. To our knowledge, this is the first reported case of CAS associated with a biclonal gammopathy and biclonal cold autoagglutinins of the IgM kappa, IgA kappa type.

摘要

一名65岁男性因前列腺肥大导致膀胱出口梗阻，偶然发现患有冷抗体自身免疫性溶血性贫血（冷凝集素综合征；CAS），原因是自身抗-I（4℃时滴度为1024，30℃时为64），并伴有双克隆丙种球蛋白病。血清和红细胞洗脱液的免疫固定电泳显示患者的自身抗体为双克隆IgM κ和IgA κ。无法确定任何潜在原因来解释双克隆丙种球蛋白病或CAS的发生。据我们所知，这是首例报道的与双克隆丙种球蛋白病以及IgM κ、IgA κ型双克隆冷自身凝集素相关的CAS病例。