Gowing N F
Pathol Annu. 1975;10:1-20.
The main histopathologic features of infectious mononucleosis are described. In the lymph nodes, the principal change is the appearance of numerous large pyroninophilic cells (immunoblasts), initially expanding the paracortical zone but later extending throughout the node. Similar, large lymphoid cells appear as infiltrates in many other organs and tissues. Cells morphologically similar to Sternberg-Reed cells may be found in the lymph nodes of patients with infectious mononucleosis and other conditions apart from Hodgkin's disease. The diagnostic importance of considering not only the Sternberg-Reed cells but their milieu is stressed. A possible relationship between infectious mononucleosis and lymphoreticular malignancy is suggested by a number of observations, but a definite etiologic link is yet to be established.
本文描述了传染性单核细胞增多症的主要组织病理学特征。在淋巴结中，主要变化是出现大量嗜派洛宁大细胞（免疫母细胞），最初这些细胞使副皮质区扩大，但随后扩展至整个淋巴结。类似的大淋巴细胞也作为浸润细胞出现在许多其他器官和组织中。形态上类似于施特恩伯格-里德细胞的细胞，可在传染性单核细胞增多症患者的淋巴结以及除霍奇金病之外的其他病症中发现。文中强调了不仅要考虑施特恩伯格-里德细胞，还要考虑其所处环境的诊断重要性。一些观察结果提示传染性单核细胞增多症与淋巴网状恶性肿瘤之间可能存在关联，但确切的病因联系尚未确立。
