Yang Hong-zhi, Wang Feng-lin, Wang Yong-ze, Shen Wei-sheng, Xu Guo-liang, Yang Yue-wu, Huang Xue-lan
The Third Affiliated Hopital, Sun Yat-sen University, Guangzhou, China.
Zhong Yao Cai. 2006 Jul;29(7):748-52.
To observe the clinical curative effect of chronic hepatitis B treated by the four-step therapeutics of Traditional Chinese Medicine (TCM).
120 patients with mild or moderate Chronic Hepatitis B (CHB) were randomly divided into two groups: 80 patients in treatment group and 40 in control group. All enrolled cases accorded with the enroll standard. In treatment group, the patients were divided into mild moderate and severe degree of immune intervention based on the ALT level and treated with four-step therapeutics according to the dialectical theory. In control group, all patients were administered 100mg Lamivudine orally daily for two years.
The loss rates of HBeAg, HBV-DNA, precore mutation were 58.9%, 78.9% in treatment group respectively, and 33.3%, 38.9% in control group. There were significant defferences between them. The total effectiveness ratio of two groups has no significant difference. After the treatment, the value of HA, PCIII, IV. C,LN decreased dramatically in treatment group and the antihepatic fibrosis results of treatment group were superior to those of control group. The four-step therapeutics of TCM could improve the ALT value and the ALT value declined to normal after the virus indexes' loss. The response rate in treatment group of ALT-elevating patients was higher than those of no ALT- elevating patients.
The four-step therapeutics of TCM is effective in treating the CHB patients.
观察中医四步疗法治疗慢性乙型肝炎的临床疗效。
将120例轻、中度慢性乙型肝炎患者随机分为两组：治疗组80例，对照组40例。所有入选病例均符合入选标准。治疗组根据ALT水平将患者分为轻度、中度和重度免疫干预，根据辨证论治采用四步疗法治疗。对照组所有患者每日口服100mg拉米夫定，疗程两年。
治疗组HBeAg、HBV-DNA丢失率及前C区变异率分别为58.9%、78.9%，对照组分别为33.3%、38.9%，两组间差异有统计学意义。两组总有效率无显著差异。治疗后，治疗组HA、PCIII、IV.C、LN值显著下降，治疗组抗肝纤维化效果优于对照组。中医四步疗法可改善ALT值，病毒指标转阴后ALT值降至正常。治疗组ALT升高患者的应答率高于ALT未升高患者。
中医四步疗法治疗慢性乙型肝炎患者有效。
