Kantathavorn Nuttavut, Phongnarisorn Chailert, Srisomboon Jatupol, Suprasert Prapaporn, Siriaunkgul Sumalee, Khunamornpong Surapan, Nimmanahaeminda Kanchana
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University Chiang Mai 50200, Thailand.
Asian Pac J Cancer Prev. 2006 Jul-Sep;7(3):477-9.
The aim of this study was to determine the underlying pathology of women with high grade squamous intraepithelial lesion (HSIL) on cervical cytology. A total of 681 women with HSIL cytology undergoing colposcopic examination at Chiang Mai University Hospital (CMUH) between January 2000 and December 2005 were evaluated for the underlying cervical pathology. The final pathology was diagnosed from the most severe lesions obtained by punch biopsy, loop electrosurgical procedure, cold knife conization or hysterectomy. Underlying high grade cervical lesions including cervical intraepithelial neoplasia grade 2, 3 and adenocarcinoma in situ were noted in 502 (73.7%) women. Invasive cervical carcinoma was identified in 141 (20.7%). The remaining 38 (5.6%) had either low grade or no intraepithelial lesions. No significant difference in the prevalence of underlying high grade and invasive lesions was noted between women with cytologic diagnosis of HSIL from CMUH and other hospitals. In conclusion, northern Thai women with HSIL cytology are at significant risk of having underlying severe cervical lesions, and especially invasive carcinoma which is detected in approximately one-fifth of the cases.
本研究的目的是确定宫颈细胞学检查显示高级别鳞状上皮内病变（HSIL）的女性的潜在病理情况。对2000年1月至2005年12月期间在清迈大学医院（CMUH）接受阴道镜检查的681例HSIL细胞学检查的女性进行了潜在宫颈病理情况评估。最终病理诊断来自通过活检钳活检、环形电切术、冷刀锥切术或子宫切除术获得的最严重病变。502例（73.7%）女性存在潜在的高级别宫颈病变，包括宫颈上皮内瘤变2级、3级和原位腺癌。141例（20.7%）确诊为浸润性宫颈癌。其余38例（5.6%）有低级别或无上皮内病变。CMUH与其他医院细胞学诊断为HSIL的女性之间，潜在高级别和浸润性病变的患病率无显著差异。总之，泰国北部HSIL细胞学检查的女性有潜在严重宫颈病变的显著风险，尤其是浸润性癌，约五分之一的病例可检测到。
