Stampachiacchiere Barbara, Aloe Luigi, Micera Alessandra, Bonini Sergio
Institute of Neurobiology and Molecular Medicine, Section of Neurobiology, National Research Council (CNR), Rome, Italy.
Exp Lung Res. 2006 Aug;32(7):305-20. doi: 10.1080/01902140600916952.
In the present study, ovalbumin-sensitized/challenged rats were characterized by an nerve growth factor (NGF) increase in both serum and bronchial alveolar lavage fluid (BALF), but not in the lung. Exogenous administration of NGF or NGF-neutralizing antibodies did not modify immunoglobulin (IgE) and eosinophil parameters. In control rats, NGF administration did not induce increase of IgE or eosinophils in both BALF and lung. The present findings suggest that at least NGF does not act as a proper proinflammatory factor but most probably as a neuroimmune modulator molecule of the allergic state.
在本研究中，卵清蛋白致敏/激发的大鼠血清和支气管肺泡灌洗液（BALF）中的神经生长因子（NGF）增加，但肺组织中未增加。外源性给予NGF或NGF中和抗体并未改变免疫球蛋白（IgE）和嗜酸性粒细胞参数。在对照大鼠中，给予NGF并未导致BALF和肺组织中IgE或嗜酸性粒细胞增加。目前的研究结果表明，至少NGF并非作为一种合适的促炎因子起作用，而很可能是作为过敏状态的神经免疫调节分子。
