Heikkilä L, Rimón R, Terenius L
Uusikaupunki Hospital, Finland.
Psychiatry Res. 1990 Dec;34(3):229-36. doi: 10.1016/0165-1781(90)90001-l.
Radioimmunoassay procedures were used to assay levels of dynorphin A (DYN A) and substance P-like activity (SP) in cerebrospinal fluid (CSF) obtained from 10 schizophrenic patients before and after neuroleptic treatment, from 10 matched patients with other psychiatric disorders before and after treatment, and from 10 nonpsychiatric surgical controls. The highest mean concentration of CSF DYN A was found in the schizophrenic group on admission (significant vs. nonpsychiatric controls). The concentration remained almost unaltered after 4 weeks of zuclopenthixol treatment despite a highly significant decrease of overt psychopathology assessed by the Brief Psychiatric Rating Scale (BPRS). There was no significant difference between the mean CSF DYN A levels of the nonschizophrenic psychiatric patients and the surgical controls. When all psychiatric patients were pooled together, there was a significant correlation between the level of CSF DYN A and the BPRS total score. With regard to CSF SP levels, no statistically significant differences were observed within or between the groups studied. Neither was there a significant correlation between the concentration of CSF SP and overt psychopathology. Nevertheless, the mean CSF SP concentration of three patients with major depression was clearly higher than the corresponding mean concentration of the other patients in the nonschizophrenic group.
采用放射免疫分析方法，对10例精神分裂症患者在接受抗精神病药物治疗前后、10例匹配的其他精神疾病患者在治疗前后以及10例非精神科手术对照者的脑脊液（CSF）中强啡肽A（DYN A）水平和P物质样活性（SP）进行测定。发现精神分裂症患者入院时脑脊液DYN A的平均浓度最高（与非精神科对照者相比有显著差异）。尽管通过简明精神病评定量表（BPRS）评估的明显精神病理学症状有高度显著下降，但在接受氯哌噻吨治疗4周后，该浓度几乎没有变化。非精神分裂症精神疾病患者的脑脊液DYN A平均水平与手术对照者之间没有显著差异。当将所有精神疾病患者合并在一起时，脑脊液DYN A水平与BPRS总分之间存在显著相关性。关于脑脊液SP水平，在所研究的组内或组间均未观察到统计学上的显著差异。脑脊液SP浓度与明显精神病理学症状之间也没有显著相关性。然而，3例重度抑郁症患者的脑脊液SP平均浓度明显高于非精神分裂症组中其他患者的相应平均浓度。
