Ala-Kokko T I, Säynäjäkangas P, Laurila P, Ohtonen P, Laurila J J, Syrjälä H
Department of Anaesthesiology, Division of Intensive Care, University of Oulu, Finland.
Anaesth Intensive Care. 2006 Oct;34(5):639-44. doi: 10.1177/0310057X0603400509.
Data from a six-year period were retrospectively retrieved from medical records and an intensive care unit data management system to study the impact of infections on patients with status epilepticus. Out of 161 admitted patients, 33 had a community-acquired infection and 35 acquired an infection during their hospital stay, 10 while in a ward before admission to the intensive care unit and 25 while in an intensive care unit, giving an infection rate of 42% of all admissions (68 patients). The patients with intensive care unit-acquired infection had three times longer stays in the intensive care unit than those without any infection (P<0.001), and they utilized almost four times more nursing resources than those without infections (P<0.001). Furthermore, they were more often sedated with thiopentone infusion, either alone or in combination with other drugs, than the non-infectious patients (80% vs 20%, P <0.001). Both community- and hospital-acquired infections were related to longer intensive care unit stays (P<0.001). The hospital stay of patients with hospital-acquired infection was threefold compared to that of patients without infection (P<0.001), and these patients utilized almost three times more nursing resources than those without any infection (P<0.001). Patients with infections consumed 65.5% of the intensive care unit nursing resources of status epilepticus patients. In conclusion, the infection rate of status epilepticus patients was high and nosocomial infections were associated with more severe illness, treatment escalation, prolonged hospital stay and enhanced resource utilization.
我们从病历和重症监护病房数据管理系统中回顾性提取了六年期间的数据，以研究感染对癫痫持续状态患者的影响。在161名入院患者中，33名发生社区获得性感染，35名在住院期间发生感染，其中10名在入住重症监护病房前在病房感染，25名在重症监护病房感染，感染率占所有入院患者的42%（68例患者）。重症监护病房获得性感染的患者在重症监护病房的住院时间比未发生任何感染的患者长三倍（P<0.001），他们使用的护理资源几乎是未感染患者的四倍（P<0.001）。此外，与未感染患者相比，他们更常单独或与其他药物联合使用硫喷妥钠输注进行镇静（80%对20%，P<0.001）。社区获得性感染和医院获得性感染均与重症监护病房住院时间延长有关（P<0.001）。医院获得性感染患者的住院时间是未感染患者的三倍（P<0.001），这些患者使用的护理资源几乎是未感染患者的三倍（P<0.001）。感染患者消耗了癫痫持续状态患者重症监护病房护理资源的65.5%。总之，癫痫持续状态患者的感染率较高，医院感染与病情更严重、治疗升级、住院时间延长和资源利用增加有关。
