Gomis Pedro, Caminal Pere, Vallverdú Montserrat, Warren Stafford, Wagner Galen
Biomedical Engineering Research Center (CREB), Department ESAII, Technical University of Catalonia, Barcelona, Spain.
Biomed Tech (Berl). 2006 Oct;51(4):178-81. doi: 10.1515/BMT.2006.031.
Coronary artery occlusions related to myocardial ischemia drive cardiac control system reactions that may lead to heart failure. The purpose of this study was to assess the autonomic nervous system (ANS) response during prolonged percutaneous transluminal coronary angioplasty (PTCA). Continuous ECG data were acquired from 50 patients before and during PTCA, with occlusions in the left anterior descending, left circumflex or right coronary artery. Heart rate variability (HRV) was analyzed for 3-min segments of the R-R interval signal obtained from ECG data. The ANS behavior was evaluated by HRV analysis using fractal-like indices. The fractal scalar exponent alpha(1) and power-law slope beta decreased considerably during PTCA. This indicates that significant reactions of autonomic control of the heart rate occurred during coronary artery occlusions, with a reduction in complexity of the ANS.
与心肌缺血相关的冠状动脉闭塞会引发心脏控制系统反应，这可能导致心力衰竭。本研究的目的是评估长时间经皮腔内冠状动脉成形术（PTCA）期间自主神经系统（ANS）的反应。在PTCA之前和期间，从50例患者获取连续心电图数据，这些患者的左前降支、左旋支或右冠状动脉存在闭塞。对从心电图数据获得的R-R间期信号的3分钟片段进行心率变异性（HRV）分析。通过使用类分形指数的HRV分析来评估ANS行为。在PTCA期间，分形标量指数α(1)和幂律斜率β显著降低。这表明在冠状动脉闭塞期间发生了心率自主控制的显著反应，同时ANS的复杂性降低。
