Niclasen Birgit V-L
Primary Healthcare Clinic, Nuuk, Greenland.
Acta Paediatr. 2006 Nov;95(11):1456-60. doi: 10.1080/08035250600686946.
To describe the changes in drug prescription to 0-14-y-old outpatient children from 1991 to 2001.
ATC codes on prescriptions were compared.
Prescriptions rose from 2.00 to 2.18 drugs/child/year, and the proportion of prescribed drugs rose from 60.7% to 70.4% of the child population (p<0.001). The 10 most prescribed subgroups accounted for 92.7% of all drugs in 0-1-y-olds and 75.9% in the schoolchildren. The individual prescription of anti-asthmatics increased by 155% (p<0.001), the use of nasal preparations and drugs against cough decreased, and more of the antibiotics were penicillin V. In 0-1-y-olds, prescriptions halved, while they nearly doubled in schoolchildren (p<0.001).
In Nuuk, a unique possibility exists: to be able to study changes in drug use and prescriptions to individual children over time from one health clinic. In the last decade, major changes have occurred regarding the number of drugs, the distribution of therapeutic subgroups, and prescriptions to all age groups. If interpreting from the magnitude of prescriptions, the prevalence of asthma doubled in this period. In summary, this study has revealed changes in prescription that can hardly be explained by changes in disease patterns. Even if unrecognized, this might also be found elsewhere.
描述1991年至2001年0至14岁门诊儿童的药物处方变化情况。
比较处方上的解剖学治疗学及化学分类代码。
处方量从每年每名儿童2.00种药物增至2.18种,开具药物的儿童比例从儿童总数的60.7%升至70.4%(p<0.001)。在0至1岁儿童中,最常开具的10个亚组占所有药物的92.7%,在学龄儿童中占75.9%。抗哮喘药物的个体处方量增加了155%(p<0.001),鼻用制剂和止咳药物的使用减少,更多抗生素为青霉素V。在0至1岁儿童中,处方量减半,而在学龄儿童中几乎翻倍(p<0.001)。
在努克,存在一种独特的可能性:能够从一家健康诊所研究随时间推移个体儿童的药物使用和处方变化。在过去十年中,药物数量、治疗亚组分布以及所有年龄组的处方都发生了重大变化。从处方量来看,这一时期哮喘患病率翻了一番。总之,本研究揭示了一些难以用疾病模式变化来解释的处方变化。即便未被认识到,这种情况可能在其他地方也存在。