Santoro Massimo, Melillo Rosa Marina, Fusco Alfredo
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR 'G. Salvatore', c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Via S. Pansini, 5, 80131 Naples, Italy.
Eur J Endocrinol. 2006 Nov;155(5):645-53. doi: 10.1530/eje.1.02289.
Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements that generate the so-called RET/PTC oncogenes. In this review, we examine the data about the mechanisms of thyroid cell transformation, activation of downstream signal transduction pathways and modulation of gene expression induced by RET/PTC. These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease.
甲状腺乳头状癌（PTC）常与RET基因重排相关，后者可产生所谓的RET/PTC致癌基因。在本综述中，我们研究了有关RET/PTC诱导甲状腺细胞转化机制、下游信号转导通路激活以及基因表达调控的相关数据。这些发现增进了我们对PTC形成过程的理解，并为该疾病的新型治疗方法提供了依据。
