Kwon Ki-Hun, Lee Jung-Il, Hong Seung-Chyul, Seo Dae Won, Hong Seung Bong
Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Stereotact Funct Neurosurg. 2006;84(5-6):243-7. doi: 10.1159/000096498. Epub 2006 Oct 24.
Dysembryoplastic neuroepithelial tumor (DNT) is a well-known epileptogenic lesion with favorable seizure outcome after surgical resection. However, sometimes surgery may be difficult technically, and epilepsy may continue throughout the patient's lifetime despite surgical intervention. We report a case of intractable epilepsy related to DNT that was treated with gamma knife radiosurgery (GKRS). The frequency of seizure was reduced remarkably after GKRS, and finally a seizure-free state was accomplished in two years. Neuropsychological tests also showed improvement. It is suggested that GKRS may be an effective and less invasive alternative treatment for the patients in whom surgical treatment is difficult.
胚胎发育不良性神经上皮肿瘤（DNT）是一种众所周知的致痫性病变，手术切除后癫痫发作预后良好。然而，有时手术在技术上可能具有挑战性，并且尽管进行了手术干预，癫痫仍可能贯穿患者一生。我们报告一例与DNT相关的难治性癫痫患者，该患者接受了伽玛刀放射外科治疗（GKRS）。GKRS后癫痫发作频率显著降低，最终在两年内实现了无癫痫发作状态。神经心理学测试也显示有所改善。提示GKRS对于手术治疗困难的患者可能是一种有效且侵入性较小的替代治疗方法。
