Ye Wei, Schneller Stewart W
Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849-5312, USA.
J Org Chem. 2006 Oct 27;71(22):8641-3. doi: 10.1021/jo0612170.
The biological versatility of aristeromycin (carbocyclic adenosine) is limited by accompanying cytotoxicity caused ostensibly by the intracellular formation of its 5'-nucleotide derivatives. Aristeromycin derivatives that offered steric interference to this transformation at the C-5' center were sought. This paper describes the facile stereospecific synthesis, where necessary, of such C-5'-methylated aristeromycin derivatives.
阿瑞霉素（碳环腺苷）的生物学多功能性受到其5'-核苷酸衍生物在细胞内形成所导致的细胞毒性的限制。人们一直在寻找对C-5'中心的这种转化具有空间干扰作用的阿瑞霉素衍生物。本文描述了在必要时此类C-5'-甲基化阿瑞霉素衍生物的简便立体定向合成方法。
