Sica Domenic A, Lohmeier Thomas E
Section of Clinical Pharmacology and Hypertension, Virginia Commonwealth University Health System, Division of Nephrology, Box 980160, MCV Station, Richmond, VA 23298-0160, USA.
Expert Rev Med Devices. 2006 Sep;3(5):595-601. doi: 10.1586/17434440.3.5.595.
This article reviews the history and current status of an innovative nonpharmacological approach for the treatment of resistant hypertension - chronic electrical activation of the afferent limb of the carotid baroreflex. Recent studies in both normotensive and hypertensive canine models have unambiguously demonstrated sustained and clinically relevant reductions in arterial pressure and sympathetic activity in the course of prolonged baroreflex activation. Clinical trials designed to evaluate the efficacy and safety of this therapy in patients with resistant hypertension are now underway in both Europe and the USA.
本文回顾了一种用于治疗顽固性高血压的创新性非药物方法——颈动脉压力感受器反射传入支慢性电激活——的历史和现状。近期在正常血压和高血压犬类模型上开展的研究已明确表明，在长期压力感受器反射激活过程中，动脉血压和交感神经活动持续且在临床上有意义地降低。目前，欧洲和美国都正在进行旨在评估该疗法对顽固性高血压患者疗效和安全性的临床试验。
