Senn Laurence, Entenza José M, Prod'hom Guy
Infectious Diseases Service, University Hospital, Lausanne, Switzerland.
FEMS Immunol Med Microbiol. 2006 Nov;48(2):215-7. doi: 10.1111/j.1574-695X.2006.00142.x.
During a 6-year period, we isolated three Abiotrophia defectiva, six Granulicatella adiacens and two G. 'para-adiacens' strains from clinical specimens. All A. defectiva strains were isolated from immunocompetent patients with endovascular infections, whereas the Granulicatella spp. strains were isolated from immunosuppressed patients with primary bacteremia. As the capacity of bacteria to adhere to the host extracellular matrix (ECM) has been implicated in the pathogenesis of endovascular infection, we investigated the ability of A. defectiva and Granulicatella spp. isolates to bind different ECM components immobilized in microtiter plates. Adherence tests showed a strong attachment of A. defectiva strains to fibronectin, whereas Granulicatella spp. strains were not adherent. The poor adherence of Granulicatella spp. strains to the ECM could be correlated with a lower propensity to induce endocarditis.
在6年期间，我们从临床标本中分离出3株缺陷乏养菌、6株毗邻颗粒链菌和2株“类毗邻”颗粒链菌。所有缺陷乏养菌菌株均从具有免疫功能的血管内感染患者中分离得到，而颗粒链菌属菌株则从免疫抑制的原发性菌血症患者中分离得到。由于细菌黏附于宿主细胞外基质（ECM）的能力与血管内感染的发病机制有关，我们研究了缺陷乏养菌和颗粒链菌属分离株结合固定在微量滴定板上的不同ECM成分的能力。黏附试验显示，缺陷乏养菌菌株对纤连蛋白有强烈的附着，而颗粒链菌属菌株则不黏附。颗粒链菌属菌株对ECM的黏附性差可能与诱发心内膜炎的倾向较低有关。
