接受抗癌化疗儿童血液淋巴细胞中Mx A蛋白的表达

Expression of MxA protein in blood lymphocytes of children receiving anticancer chemotherapy.

作者信息

Koskenvuo Minna M, Halminen Markus, Blomqvist Miia, Vainionpää Raija, Ilonen Jorma, Julkunen Ilkka, Salmi Toivo T, Mäkelä Mika J

机构信息

Turku Immunology Centre and Departments of Pediatrics and Virology, University of Turku, Turku, Finland.

出版信息

Pediatr Hematol Oncol. 2006 Dec;23(8):649-60. doi: 10.1080/08880010600956863.

DOI:10.1080/08880010600956863

PMID:17065141

Abstract

The aim of the study was to evaluate whether IFN-alpha/beta-inducible MxA protein expression in children receiving anticancer treatment can be used as an indicator for virus infections during the febrile episodes. Twenty-six children with mainly hematological malignancies entered the study. Children with laboratory-confirmed virus infections had clearly elevated MxA protein levels compared to their counterparts with bacterial or unknown etiology. MxA protein expression increased moderately following the administration of cytostatic agents, even though these children had no clinical signs of infection.

摘要

该研究的目的是评估接受抗癌治疗的儿童中，α/β干扰素诱导的Mx A蛋白表达是否可作为发热期间病毒感染的指标。26名主要患有血液系统恶性肿瘤的儿童参与了该研究。与细菌感染或病因不明的儿童相比，实验室确诊为病毒感染的儿童Mx A蛋白水平明显升高。即使这些儿童没有感染的临床症状，在给予细胞毒性药物后，Mx A蛋白表达仍适度增加。