Jayabose Somasundaram, Levendoglu-Tugal Oya, Ozkaynak Mehmet F, Sandoval Claudio
Department of Pediatrics, New York Medical College, Valhalla, New York, USA.
Pediatr Hematol Oncol. 2006 Dec;23(8):677-82. doi: 10.1080/08880010600962143.
Recurrent immune thrombocytopenic purpura (ITP) is defined as the recurrence of ITP after at least 3 months of remission sustained without treatment. Among 340 children with ITP, 14 had recurrent ITP (4.1%). Ten were females. The initial course was acute in 8 patients and chronic in 6. The median time to recurrence was 33 months (range 4-120). Only 1 patient had a second recurrence. Twelve (86%) achieved complete (n = 10) or partial (n = 2) remission, two of them after splenectomy. One patient continued to require treatment at 10 months from recurrence. One child died of intracranial hemorrhage despite aggressive treatment including splenectomy and craniotomy.
复发性免疫性血小板减少性紫癜（ITP）定义为在未经治疗持续缓解至少3个月后ITP复发。在340例ITP患儿中，14例有复发性ITP（4.1%）。其中10例为女性。8例患者初始病程为急性，6例为慢性。复发的中位时间为33个月（范围4 - 120个月）。仅1例患者有第二次复发。12例（86%）实现完全缓解（n = 10）或部分缓解（n = 2），其中2例在脾切除术后缓解。1例患者在复发10个月后仍需治疗。1例患儿尽管接受了包括脾切除术和开颅手术在内的积极治疗，仍死于颅内出血。
