儿童复发性免疫性血小板减少性紫癜

Recurrent immune thrombocytopenic purpura in children.

作者信息

Jayabose Somasundaram, Levendoglu-Tugal Oya, Ozkaynak Mehmet F, Sandoval Claudio

机构信息

Department of Pediatrics, New York Medical College, Valhalla, New York, USA.

出版信息

Pediatr Hematol Oncol. 2006 Dec;23(8):677-82. doi: 10.1080/08880010600962143.

DOI:10.1080/08880010600962143

PMID:17065144

Abstract

Recurrent immune thrombocytopenic purpura (ITP) is defined as the recurrence of ITP after at least 3 months of remission sustained without treatment. Among 340 children with ITP, 14 had recurrent ITP (4.1%). Ten were females. The initial course was acute in 8 patients and chronic in 6. The median time to recurrence was 33 months (range 4-120). Only 1 patient had a second recurrence. Twelve (86%) achieved complete (n = 10) or partial (n = 2) remission, two of them after splenectomy. One patient continued to require treatment at 10 months from recurrence. One child died of intracranial hemorrhage despite aggressive treatment including splenectomy and craniotomy.

摘要

复发性免疫性血小板减少性紫癜（ITP）定义为在未经治疗持续缓解至少3个月后ITP复发。在340例ITP患儿中，14例有复发性ITP（4.1%）。其中10例为女性。8例患者初始病程为急性，6例为慢性。复发的中位时间为33个月（范围4 - 120个月）。仅1例患者有第二次复发。12例（86%）实现完全缓解（n = 10）或部分缓解（n = 2），其中2例在脾切除术后缓解。1例患者在复发10个月后仍需治疗。1例患儿尽管接受了包括脾切除术和开颅手术在内的积极治疗，仍死于颅内出血。