Herzog Erica L, Krause Diane S
Department of Laboratory Medicine, 333 Cedar Street, P.O. Box 208035, Yale University School of Medicine, New Haven, CT 06520-8035, USA.
Proc Am Thorac Soc. 2006 Nov;3(8):691-5. doi: 10.1513/pats.200605-109SF.
Contribution of transplanted bone marrow has, in many models, led to the appearance of marrow-derived epithelial cells in a variety of organs, including the lung. Following the initial descriptions of these cells, many questions remain about the mechanisms by which bone marrow adopts an epithelial phenotype in the murine lung. Data from other epithelial lineages, such as those of the kidney and colon, suggest that one mechanism is fusion of transplanted marrow with host pneumocytes. This process appears to require severe damage and may not be the only mechanism by which mature lung epithelia can derive from marrow. This article discusses the processes leading to the appearance of marrow-derived pneumocytes and highlights the therapeutic potential of bone marrow to fuse with or differentiate into epithelial cells of the lung.
在许多模型中，移植骨髓的贡献导致了包括肺在内的多种器官中出现骨髓来源的上皮细胞。在对这些细胞进行初步描述之后，关于骨髓在小鼠肺中呈现上皮表型的机制仍存在许多问题。来自其他上皮谱系（如肾和结肠）的数据表明，一种机制是移植的骨髓与宿主肺细胞融合。这个过程似乎需要严重损伤，并且可能不是成熟肺上皮细胞能够从骨髓衍生而来的唯一机制。本文讨论了导致骨髓来源的肺细胞出现的过程，并强调了骨髓与肺上皮细胞融合或分化的治疗潜力。
