正常人体内房水流动在早晨和夜间的一致性。

Radenbaugh Pauline A, Goyal Anju, McLaren Ning C, Reed David M, Musch David C, Richards Julia E, Moroi Sayoko E

Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA.

Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4860-4. doi: 10.1167/iovs.06-0154.

PURPOSE

To test the hypothesis that an individual shows concordance of aqueous humor flow in the morning and at night in a prospective inpatient fluorophotometry study in healthy subjects.

METHODS

Flow was measured in each eye every hour between 8 AM and noon and every 2 hours between midnight and 6 AM. Morning and nighttime flows were analyzed for differences between eyes and for differences between these two time points. Concordance of individual morning and nighttime flows were studied by categorization into low, medium, or high tertiles, dot plot, and ordinary least-squares regression (OLS) scatter plot.

RESULTS

In 28 subjects, the flow was similar between eyes within a subject with healthy eyes. In the one eye examined in each subject, the average flow was 3.12 +/- 1.09 muL/min in the morning, which decreased significantly to 1.59 +/- 0.58 muL/min at night. During each time period, the individual flow data were normally distributed. Concordance of an individual's morning and nighttime flows was 68%. A scatter plot of morning versus nighttime flows also supported concordance with an OLS regression fit of r(2) = 0.45.

CONCLUSIONS

The results provide evidence that aqueous humor flow is similar between eyes, that flow variation shows a normal distribution, and that individuals show a concordance of flow in the morning and at night. These observations support the posit that aqueous humor flow, which is a factor that contributes to the important clinical risk factor of IOP variation, is amenable to study as a quantitative trait.

目的

在一项针对健康受试者的前瞻性住院荧光光度法研究中，检验个体在早晨和晚上房水流量具有一致性这一假设。

方法

在上午8点至中午之间，每小时测量每只眼睛的流量；在午夜至凌晨6点之间，每两小时测量一次。分析早晨和夜间的流量，以比较两眼之间的差异以及这两个时间点之间的差异。通过分类为低、中、高三分位数、点图和普通最小二乘回归（OLS）散点图，研究个体早晨和夜间流量的一致性。

结果

在28名受试者中，健康眼睛的受试者两眼之间的流量相似。在每个受试者检查的一只眼睛中，早晨的平均流量为3.12±1.09μL/分钟，夜间显著降至1.59±0.58μL/分钟。在每个时间段内，个体流量数据呈正态分布。个体早晨和夜间流量的一致性为68%。早晨与夜间流量的散点图也支持一致性，OLS回归拟合的r(2)=0.45。