睡眠状态下人体的房水流动不受去甲肾上腺素输注的影响。

Aqueous humor flow in sleeping humans is unaffected by norepinephrine infusion.

作者信息

Vanlandingham B D, FitzSimon J S, Brubaker R F

机构信息

Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.

出版信息

Invest Ophthalmol Vis Sci. 1998 Aug;39(9):1759-62.

PMID:9699568

Abstract

PURPOSE

Intravenous administration of the catecholamine epinephrine is known to have a stimulatory effect on aqueous humor flow in sleeping human subjects, an effect that is augmented by plasma corticosteroids. This study was performed to determine whether the closely related catecholamine norepinephrine has a similar effect on aqueous humor flow.

METHODS

Twenty normal subjects were studied. Aqueous flow was measured by fluorophotometry. At night during sleep, norepinephrine or placebo was infused intravenously (i.v.) between midnight and 6 AM. The rate of aqueous flow during the norepinephrine infusion was compared with the rate of flow during placebo infusion, with each subject serving as his/her own control. The urinary excretions of epinephrine and norepinephrine were measured at the end of each infusion period.

RESULTS

The norepinephrine infusion caused an 8% increase in systolic blood pressure (P < 0.001), a 15% increase in diastolic blood pressure (P < 0.001), and a 9% decrease in heart rate (P=0.003) compared with the placebo. The rate of aqueous humor flow during sleep from 12 AM to 6 AM was unchanged by norepinephrine. The rate was 1.27+/-0.31 microl/min (mean+/-SD) during i.v. infusion of placebo and 1.30+/-0.27 microl/min during infusion of norepinephrine (P=0.63).

CONCLUSIONS

An infusion of norepinephrine during sleep that causes measurable changes in cardiovascular parameters has no measurable effects on the rate of aqueous humor flow. The lack of a measurable effect of a norepinephrine infusion contrasts to the stimulatory effect of an epinephrine infusion.

摘要

目的

已知静脉注射儿茶酚胺肾上腺素对睡眠中的人类受试者房水流出具有刺激作用，血浆皮质类固醇可增强这种作用。本研究旨在确定密切相关的儿茶酚胺去甲肾上腺素对房水流出是否有类似作用。

方法

对20名正常受试者进行研究。通过荧光光度法测量房水流量。在夜间睡眠期间，于午夜至凌晨6点静脉内输注去甲肾上腺素或安慰剂。将去甲肾上腺素输注期间的房水流量速率与安慰剂输注期间的流量速率进行比较，每位受试者作为自身对照。在每个输注期结束时测量肾上腺素和去甲肾上腺素的尿排泄量。

结果

与安慰剂相比，去甲肾上腺素输注导致收缩压升高8%（P<0.001），舒张压升高15%（P<0.001），心率降低9%（P = 0.003）。去甲肾上腺素未改变凌晨12点至6点睡眠期间的房水流量速率。静脉输注安慰剂期间的速率为1.27±0.31微升/分钟（平均值±标准差），输注去甲肾上腺素期间为1.30±0.27微升/分钟（P = 0.63）。