酸和酸化亚硝酸盐对医院病原体的体外杀灭作用
In vitro killing of nosocomial pathogens by acid and acidified nitrite.
作者信息
Rao Agam, Jump Robin L P, Pultz Nicole J, Pultz Michael J, Donskey Curtis J
机构信息
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA.
出版信息
Antimicrob Agents Chemother. 2006 Nov;50(11):3901-4. doi: 10.1128/AAC.01506-05.
Abstract
Exposure to pH 1 or 2 buffers or acidic gastric contents resulted in the killing of vancomycin-resistant Enterococcus sp., Klebsiella pneumoniae, Staphylococcus aureus, and Candida glabrata but not Clostridium difficile spores. Nitrite enhanced killing under acidic conditions, but significant killing of C. difficile spores required nitrite concentrations above usual physiological levels.
摘要
暴露于pH值为1或2的缓冲液或酸性胃内容物会导致耐万古霉素肠球菌、肺炎克雷伯菌、金黄色葡萄球菌和光滑念珠菌死亡，但艰难梭菌孢子不会死亡。亚硝酸盐在酸性条件下会增强杀菌效果，但要显著杀死艰难梭菌孢子需要亚硝酸盐浓度高于正常生理水平。
相似文献
1
In vitro killing of nosocomial pathogens by acid and acidified nitrite.酸和酸化亚硝酸盐对医院病原体的体外杀灭作用
Antimicrob Agents Chemother. 2006 Nov;50(11):3901-4. doi: 10.1128/AAC.01506-05.
2
Multihospital surveillance of nosocomial methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococcus, and Clostridium difficile: analysis of a 4-year data-sharing project, 1999-2002.多医院耐甲氧西林金黄色葡萄球菌、耐万古霉素肠球菌和艰难梭菌的监测：1999 - 2002年一项为期4年的数据共享项目分析
Am J Infect Control. 2006 Sep;34(7):458-64. doi: 10.1016/j.ajic.2005.08.010.
3
Multidrug-resistant bacteria in hospitalized children: a 5-year multicenter study.住院儿童中的多重耐药菌：一项为期5年的多中心研究。
Pediatrics. 2007 Apr;119(4):e798-803. doi: 10.1542/peds.2006-1384.
4
"Collateral damage" from cephalosporin or quinolone antibiotic therapy.头孢菌素或喹诺酮类抗生素治疗的“附带损害”
Clin Infect Dis. 2004 May 15;38 Suppl 4:S341-5. doi: 10.1086/382690.
5
Growth and geographic variation in hospitalizations with resistant infections, United States, 2000-2005.2000 - 2005年美国耐药感染住院情况的增长及地理差异
Emerg Infect Dis. 2008 Nov;14(11):1756-8. doi: 10.3201/eid1411.080337.
6
Nosocomial infections due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus: relationships with antibiotic use and cost drivers.耐甲氧西林金黄色葡萄球菌和耐万古霉素肠球菌引起的医院感染：与抗生素使用及成本驱动因素的关系
Ann Pharmacother. 2008 Mar;42(3):317-26. doi: 10.1345/aph.1K501. Epub 2008 Feb 19.
7
Acidified nitrite: a host defence against colonization with C. difficile spores?酸化亚硝酸盐：宿主防御艰难梭菌孢子定植的手段？
J Hosp Infect. 2014 Feb;86(2):155-7. doi: 10.1016/j.jhin.2013.12.003. Epub 2013 Dec 21.
8
Superbugs in the coming new decade; multidrug resistance and prospects for treatment of Staphylococcus aureus, Enterococcus spp. and Pseudomonas aeruginosa in 2010.未来十年的超级细菌；2010年金黄色葡萄球菌、肠球菌属和铜绿假单胞菌的多重耐药性及治疗前景
Curr Opin Microbiol. 2007 Oct;10(5):436-40. doi: 10.1016/j.mib.2007.07.004. Epub 2007 Aug 30.
9
Prevalence of enterotoxin producing Staphylococcus aureus in stools of patients with nosocomial diarrhea.医院获得性腹泻患者粪便中产肠毒素金黄色葡萄球菌的患病率
Infection. 2007 Oct;35(5):356-8. doi: 10.1007/s15010-007-6268-8. Epub 2007 Aug 25.
10
Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a Phase 3, multicentre, double-blind, randomized study.替加环素与万古霉素或利奈唑胺治疗耐甲氧西林金黄色葡萄球菌或耐万古霉素肠球菌严重感染的疗效及安全性：一项3期、多中心、双盲、随机研究
J Antimicrob Chemother. 2008 Sep;62 Suppl 1:i17-28. doi: 10.1093/jac/dkn250.
引用本文的文献
1
Natural and induced immune responses in oral cavity and saliva.口腔和唾液中的天然免疫反应与诱导免疫反应。
BMC Immunol. 2025 Apr 18;26(1):34. doi: 10.1186/s12865-025-00713-8.
2
Gut Microbiota Composition Associated with Colonization and Infection.与定植和感染相关的肠道微生物群组成
Pathogens. 2022 Jul 8;11(7):781. doi: 10.3390/pathogens11070781.
3
Ischemic Colitis Is a Risk Factor for Clostridium difficile Infection.缺血性结肠炎是艰难梭菌感染的一个危险因素。
Cureus. 2022 Jun 19;14(6):e26076. doi: 10.7759/cureus.26076. eCollection 2022 Jun.
4
Achieving Partial Nitritation by Treating Sludge With Free Nitrous Acid: The Potential Role of Quorum Sensing.通过用游离亚硝酸处理污泥实现部分亚硝化：群体感应的潜在作用。
Front Microbiol. 2022 Apr 27;13:897566. doi: 10.3389/fmicb.2022.897566. eCollection 2022.
5
Fate of Methicillin-resistant (MRSA) under simulated acidic conditions of the human stomach.耐甲氧西林金黄色葡萄球菌（MRSA）在模拟人体胃部酸性条件下的命运。
Food Sci Nutr. 2020 Jul 31;8(9):4739-4745. doi: 10.1002/fsn3.1698. eCollection 2020 Sep.
6
Regularized S-Map Reveals Varying Bacterial Interactions.正则化 S-Map 揭示了不同的细菌相互作用。
Appl Environ Microbiol. 2020 Oct 1;86(20). doi: 10.1128/AEM.01615-20.
7
Causes, Burden, and Prevention of Infection.感染的病因、负担及预防
Infect Dis Clin Pract (Baltim Md). 2015 May;23(6):281-288. doi: 10.1097/IPC.0000000000000331.
8
Vancomycin-Resistant Acquisition in a Tertiary Care Hospital: Testing the Roles of Antibiotic Use, Proton Pump Inhibitor Use, and Colonization Pressure.三级医疗医院中耐万古霉素的获得情况：探究抗生素使用、质子泵抑制剂使用及定植压力的作用
Open Forum Infect Dis. 2019 Mar 15;6(4):ofz139. doi: 10.1093/ofid/ofz139. eCollection 2019 Apr.
9
The Clinician's Guide to Proton Pump Inhibitor Related Adverse Events.质子泵抑制剂相关不良反应的临床指南。
Drugs. 2019 May;79(7):715-731. doi: 10.1007/s40265-019-01110-3.
10
colitis and zoonotic origins-a narrative review.结肠炎与动物源性起源——一篇叙述性综述
Gastroenterol Rep (Oxf). 2018 Aug;6(3):157-166. doi: 10.1093/gastro/goy016. Epub 2018 Jun 28.
本文引用的文献
1
Influx of extended-spectrum beta-lactamase-producing enterobacteriaceae into the hospital.产超广谱β-内酰胺酶肠杆菌科细菌流入医院。
Clin Infect Dis. 2006 Apr 1;42(7):925-34. doi: 10.1086/500936. Epub 2006 Feb 27.
2
Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease.使用胃酸抑制剂与社区获得性艰难梭菌相关疾病的风险
JAMA. 2005 Dec 21;294(23):2989-95. doi: 10.1001/jama.294.23.2989.
3
Vancomycin-resistant enterococcal colonization and infection in liver transplant candidates and recipients: a prospective surveillance study.肝移植候选者和受者中耐万古霉素肠球菌的定植与感染：一项前瞻性监测研究。
Clin Infect Dis. 2006 Jan 15;42(2):195-203. doi: 10.1086/498903. Epub 2005 Dec 12.
4
Growth in cecal mucus facilitates colonization of the mouse intestinal tract by methicillin-resistant Staphylococcus aureus.盲肠黏液的生长促进耐甲氧西林金黄色葡萄球菌在小鼠肠道内的定殖。
J Infect Dis. 2005 Nov 1;192(9):1621-7. doi: 10.1086/491737. Epub 2005 Sep 28.
5
Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice.胃肠外给予抗生素对成年小鼠光滑念珠菌肠道定植的影响。
Antimicrob Agents Chemother. 2005 Jan;49(1):438-40. doi: 10.1128/AAC.49.1.438-440.2005.
6
Has the epidemiology of nosocomial candidemia changed?医院念珠菌血症的流行病学有变化吗？
Infect Control Hosp Epidemiol. 2004 Aug;25(8):628-33. doi: 10.1086/502452.
7
The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens.肠道作为医院感染病原体储存库和传播源的作用。
Clin Infect Dis. 2004 Jul 15;39(2):219-26. doi: 10.1086/422002. Epub 2004 Jun 25.
8
Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies.住院患者中开具质子泵抑制剂处方后发生艰难梭菌腹泻的风险：队列研究和病例对照研究
CMAJ. 2004 Jul 6;171(1):33-8. doi: 10.1503/cmaj.1040876.
9
Effects of ascorbic acid, glutathione, thiocyanate, and iodide on antimicrobial activity of acidified nitrite.抗坏血酸、谷胱甘肽、硫氰酸盐和碘化物对酸化亚硝酸盐抗菌活性的影响。
Antimicrob Agents Chemother. 2004 Feb;48(2):655-8. doi: 10.1128/AAC.48.2.655-658.2004.
10
Prevention of fatal Clostridium difficile-associated disease during continuous administration of clindamycin in hamsters.在仓鼠连续给予克林霉素期间预防致命的艰难梭菌相关疾病
J Infect Dis. 2003 Dec 15;188(12):1922-7. doi: 10.1086/379836. Epub 2003 Dec 9.
Zotero 插件