Pankuch G A, Appelbaum P C
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Antimicrob Agents Chemother. 2006 Nov;50(11):3956-8. doi: 10.1128/AAC.00724-06.
The in vitro postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects of ceftobiprole were determined for 12 gram-positive organisms. Pneumococcal, staphylococcal, and enterococcal PAEs were 1.4 to 3.1 h, 0 to 1.8 h, and 0 to 0.9 h, respectively. The PA-SMEs (0.4 times the MIC) for pneumococci, staphylococci, and enterococci were 4.8 to >10.3 h, 1.5 to 9.6 h, and 3.8 to >10.7 h, respectively.
对12种革兰氏阳性菌测定了头孢托罗的体外抗生素后效应（PAEs）、亚抑菌浓度抗生素后效应（PA-SMEs）及亚抑菌浓度效应。肺炎球菌、葡萄球菌和肠球菌的PAEs分别为1.4至3.1小时、0至1.8小时和0至0.9小时。肺炎球菌、葡萄球菌和肠球菌的PA-SMEs（0.4倍MIC）分别为4.8至>10.3小时、1.5至9.6小时和3.8至>10.7小时。
