Igea J M, Quirce S, de la Hoz B, Fraj J, Pola J, Diez Gomez M L
Servicio de Alergia, Hospital Ramon y Cajal, Carretera de Colmenar, Madrid, Spain.
Ann Allergy. 1991 Mar;66(3):216-8.
Macrolides, which are widely prescribed and seldom produce hypersensitivity reactions, are considered to be safe drugs. We present five patients with generalized skin reactions due to erythromycin and/or spiramycin, proved by oral challenge tests. One patient showed reactions to both erythromycin and spiramycin. All skin prick and patch tests and histamine release tests with both macrolides were negative.
大环内酯类药物广泛应用于临床，很少引起过敏反应，被认为是安全的药物。我们报告5例因红霉素和/或螺旋霉素引起全身性皮肤反应的患者，经口服激发试验证实。1例患者对红霉素和螺旋霉素均有反应。两种大环内酯类药物的所有皮肤点刺试验、斑贴试验及组胺释放试验均为阴性。
