Arnheiter H, Meier E
Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
New Biol. 1990 Oct;2(10):851-7.
The interferon-inducible Mx1 protein is responsible for inborn resistance of mice to influenza. It is now recognized that this protein is a member of a family of interferon-inducible, putative GTP-binding proteins found in many organisms. Thus, these proteins, called the Mx proteins, are found in species that are naturally infected with influenza virus, and also in species that are not. Some Mx proteins display a broader antiviral profile than the one observed for Mx1 in mice. Others, however, may not be antiviral. Two recently discovered GTP-binding proteins, Vps1p in yeast and dynamin in rat, are also related to Mx1. These proteins are synthesized constitutively and serve basic cellular functions.
干扰素诱导的Mx1蛋白负责小鼠对流感的先天抵抗力。现在人们认识到，这种蛋白是在许多生物体中发现的干扰素诱导的、假定的GTP结合蛋白家族的成员。因此，这些被称为Mx蛋白的蛋白，在自然感染流感病毒的物种中存在，也在未感染的物种中存在。一些Mx蛋白显示出比在小鼠中观察到的Mx1更广泛的抗病毒谱。然而，其他一些Mx蛋白可能不具有抗病毒作用。最近发现的两种GTP结合蛋白，酵母中的Vps1p和大鼠中的发动蛋白，也与Mx1有关。这些蛋白是组成性合成的，并发挥基本的细胞功能。
