Yao Chen, Wang Shen-ming, Xie Dan, Wu Hui-xi, Chen Dong-ying, Lin Ying
Center of Breast Disease, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Zhonghua Wai Ke Za Zhi. 2006 Jul 1;44(13):900-3.
To investigate the expression of interleukin-8 (IL-8) and its prognostic significance in breast cancer.
Expression of IL-8 in 113 breast cancers, 19 breast benign tumors and 20 breast normal tissues was examined by tissue microarray using immunohistochemistry, and the association of IL-8 expression with patient's clinico-pathological characteristics and prognosis was further analyzed.
The positive rate of IL-8 expression in breast cancer was 27.4%, which was significantly higher than that in benign tumor and normal tissue of breast (P = 0.002). IL-8 expression related to histological type (P = 0.040) and lymph node status (P = 0.021). The expression of IL-8 was observed to correlate negatively with ER and PR status (P = 0.015 and P = 0.034), and correlate positively with C-erbB-2 status (P = 0.002). In addition, Kaplan-Meier curves of disease-free survival analysis showed a significant difference between IL-8 positive groups and negative group (P = 0.031).
IL-8 might be a poor prognostic factor for human breast cancer, and also might be a novel molecular marker to predicate the occurrence and progression of breast cancer.
探讨白细胞介素-8（IL-8）在乳腺癌中的表达及其预后意义。
采用组织芯片免疫组化法检测113例乳腺癌、19例乳腺良性肿瘤及20例乳腺正常组织中IL-8的表达，并进一步分析IL-8表达与患者临床病理特征及预后的关系。
结果：乳腺癌中IL-8表达阳性率为27.4%，显著高于乳腺良性肿瘤及正常组织（P = 0.002）。IL-8表达与组织学类型（P = 0.040）及淋巴结状态（P = 0.021）有关。观察到IL-8表达与ER和PR状态呈负相关（P = 0.015和P = 0.034），与C-erbB-2状态呈正相关（P = 0.002）。此外，无病生存分析的Kaplan-Meier曲线显示IL-8阳性组与阴性组之间存在显著差异（P = 0.031）。
IL-8可能是人类乳腺癌的不良预后因素，也可能是预测乳腺癌发生和进展的新型分子标志物。
