Bravo Gabriela, Maswood Sharmin
Department of Psychology, Franklin and Marshall College, Lancaster, PA 17604, USA.
Pharmacol Biochem Behav. 2006 Oct;85(2):362-8. doi: 10.1016/j.pbb.2006.09.003. Epub 2006 Oct 25.
The effects of tropisetron, a 5-HT3 receptor antagonist, were evaluated in adult Fischer female rats exposed to the Forced Swim Test (FST). Rats selected on the days of proestrus or estrus was immersed in a cylinder of water for 2 consecutive days. Rats were exposed to the FST for 15 min on day 1 (pretest), followed by a 5-min session (test), 24 h later. The proestrous-estrous group consisted of rats that were exposed to the FST on their proestrous stage (pretest); then 24 h later the same rats were exposed to the FST on their estrous stage (test). Rats in the estrous-diestrous group were exposed to the FST on their estrous stage (pretest) and 24 h later on their diestrous stage (test). Rats were injected intraperitoneally with saline or 1.0 or 2.0 mg/kg tropisetron 30 min prior to exposure to the cylinder on the test day. Immobility, swimming, and struggling behaviors were scored for 5 min. There was a significant decline in immobility after treatment with 2.0 mg/kg tropisetron in both groups. In addition, a significant decline in swimming was observed in the estrous rats (proestrous-estrous group) after treatment with 2.0 mg/kg tropisetron. There were no significant effects of tropisetron on struggling in any groups examined.
在成年雌性Fischer大鼠中进行强迫游泳试验（FST），以评估5-羟色胺3（5-HT3）受体拮抗剂托烷司琼的作用。在动情前期或动情期挑选的大鼠连续2天被浸入盛有水的圆筒中。第1天（预试验）让大鼠进行15分钟的FST，24小时后进行5分钟的试验。动情前期-动情期组由在动情前期阶段进行FST（预试验）的大鼠组成；然后24小时后，同样的大鼠在动情期阶段进行FST（试验）。动情期-动情后期组的大鼠在动情期阶段进行FST（预试验），24小时后在动情后期阶段进行FST（试验）。在试验当天，大鼠在被放入圆筒前30分钟腹腔注射生理盐水或1.0或2.0mg/kg托烷司琼。对不动、游泳和挣扎行为进行5分钟的评分。两组中，用2.0mg/kg托烷司琼治疗后，不动行为显著减少。此外，用2.0mg/kg托烷司琼治疗后，动情期大鼠（动情前期-动情期组）的游泳行为显著减少。在任何受试组中，托烷司琼对挣扎行为均无显著影响。
