Bazi Tony M, Hamade Ramsey F, Abdallah Hajj Hussein Inaya, Abi Nader Khalil, Jurjus Abdo
Department of Obstetrics and Gynecology, American University of Beirut, Beirut, Lebanon.
Eur Urol. 2007 May;51(5):1364-73; discussion 1373-5. doi: 10.1016/j.eururo.2006.10.002. Epub 2006 Oct 18.
To evaluate the biomechanical properties and histologic changes of different commercially available polypropylene midurethral tapes (MUTs) after implantation in the rat.
Pieces of Advantage, intravaginal slingplasty (IVS), suprapubic arch sling (SPARC), and tension-free vaginal tape (TVT) were implanted over the rectus fascia of rats, with six rats serving as controls. On retrieval 24 wk later, the degree of adherence and sample measurements were recorded. Biomechanical testing of the retrieved samples was performed using the uniaxial loading method. Histologic evaluation of the samples under light microscopy included the following parameters: inflammatory infiltrate, fibrosis, mast cell presence, muscular infiltration, and collagen filling of the mesh.
No mesh extrusion or infection was encountered. The biomechanical and histologic results were consistent within each group. TVT displayed peculiar adherence characteristics not found among the other brands. No statistically significant difference were found in mean peak load and extension at peak load among the four tested brands. Stiffness of TVT was significantly lower than that of each of the other three brands. Stiffness of Advantage was significantly higher than that of SPARC. The histologic findings differed from one MUT brand to another. By grading certain histologic parameters, an untested model to assign a score for biocompatibility potential in the rat, to different MUTs, was developed.
Commercially available polypropylene MUTs display different biologic and biomechanical properties in the rat.
评估不同市售聚丙烯中尿道吊带（MUTs）植入大鼠后其生物力学特性和组织学变化。
将Advantage、阴道内吊带成形术（IVS）、耻骨上弓吊带（SPARC）和无张力阴道吊带（TVT）的片段植入大鼠腹直肌筋膜上，6只大鼠作为对照。24周后取出时，记录粘连程度和样本测量值。对取出的样本采用单轴加载法进行生物力学测试。在光学显微镜下对样本进行组织学评估，包括以下参数：炎性浸润、纤维化、肥大细胞存在情况、肌肉浸润以及网片的胶原填充情况。
未出现网片挤出或感染情况。每组内生物力学和组织学结果一致。TVT表现出其他品牌未发现的特殊粘连特性。在四个测试品牌中，平均峰值负荷和峰值负荷时的伸长率未发现统计学显著差异。TVT的刚度显著低于其他三个品牌中的任何一个。Advantage的刚度显著高于SPARC。不同MUT品牌的组织学结果有所不同。通过对某些组织学参数进行分级，开发了一种未经验证的模型，用于为大鼠体内不同MUTs的生物相容性潜力评分。
市售聚丙烯MUTs在大鼠体内表现出不同的生物学和生物力学特性。
