Torisawa Yasuhiro, Nishi Takao, Minamikawa Jun-ichi
Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Naka-Orui, Takasaki, Gunma 370-0033, Japan.
Bioorg Med Chem Lett. 2007 Jan 15;17(2):448-52. doi: 10.1016/j.bmcl.2006.10.019. Epub 2006 Oct 12.
Continuing search for beneficial additive toward the Beckmann rearrangement (BR) of indanone oxime has revealed that common Lewis acid catalyst in methanesulfonyl chloride (MsCl) showed increasing efficiency in this ionic rearrangement. The new protocol with MsCl is superior to the classical phosphorus-based methods such as PPA and Eaton reagent, especially in the reaction of indanone oximes.
对茚满酮肟的贝克曼重排（BR）持续寻找有益添加剂的研究表明，甲磺酰氯（MsCl）中的常见路易斯酸催化剂在这种离子重排反应中显示出越来越高的效率。使用MsCl的新方案优于经典的基于磷的方法，如多聚磷酸（PPA）和伊顿试剂，特别是在茚满酮肟的反应中。
