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降钙素基因相关肽对包括人在内的各种哺乳动物中激动剂诱导的支气管收缩的抑制作用。

Inhibition by calcitonin gene-related peptide of agonist-induced bronchoconstriction in various mammals including man.

作者信息

Cadieux A, Lanoue C

机构信息

Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.

出版信息

Agents Actions Suppl. 1990;31:211-4. doi: 10.1007/978-3-0348-7379-6_26.

DOI:10.1007/978-3-0348-7379-6_26
PMID:1706906
Abstract

The effect of calcitonin gene-related peptide (CGRP) on the smooth muscle of mammalian airways has been investigated in vitro. CGRP itself lacked contractile activity but reduced responses evoked by bronchoconstrictor agents via a post-junctional action. The inhibitory effect of CGRP was concentration-related and greatest in distal airways. The results suggest that CGRP may contribute to regulating muscular tone in the tracheobronchial tree.

摘要

降钙素基因相关肽（CGRP）对哺乳动物气道平滑肌的作用已在体外进行了研究。CGRP本身缺乏收缩活性，但通过接头后作用降低了支气管收缩剂引起的反应。CGRP的抑制作用与浓度相关，在远端气道中作用最强。结果表明，CGRP可能有助于调节气管支气管树的肌肉张力。

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