Fedorova N V, Levin O S, Smolentseva I G, Kulua T K
Zh Nevrol Psikhiatr Im S S Korsakova. 2006;106(9):39-46.
Based on literature data on the usage of Dopa medications in the treatment of Parkinson's disease (PD), a characteristic of a new complex drug stalevo, which includes levodopa, carbidopa and entacapon (catechol-O-methyltransferase inhibitor), is presented. The authors studied 15 patients with PD, aged 55.6+/-8.7 years, illness duration 7.7+/-3.1 years, who received stalevo during 6 weeks and revealed that stalevo reduced significantly the intensity of main PD symptoms, especially hypotension and rigidity as well as motor fluctuations, and improved general movement and daily activity of patients thus ameliorating their quality of life. The drug is well-tolerable.
基于关于多巴类药物在帕金森病(PD)治疗中应用的文献数据,介绍了一种新型复方药物Stalevo的特性,该药物包含左旋多巴、卡比多巴和恩他卡朋(儿茶酚-O-甲基转移酶抑制剂)。作者研究了15例帕金森病患者,年龄为55.6±8.7岁,病程为7.7±3.1年,这些患者接受了6周的Stalevo治疗,结果显示Stalevo显著降低了帕金森病主要症状的强度,尤其是低血压和僵硬以及运动波动,并改善了患者的总体运动能力和日常活动,从而提高了他们的生活质量。该药物耐受性良好。