Polednak Anthony P
Connecticut Department of Public Health, Hartford, CT 06134-0308, USA.
Cancer Detect Prev. 2006;30(5):466-72. doi: 10.1016/j.cdp.2006.07.003. Epub 2006 Oct 27.
The few studies that have examined the association between comorbid diabetes mellitus (DM) and survival after diagnosis of colorectal cancer have involved small numbers of patients with DM, and cause of death was not examined.
All 542 African American (black) and 8,853 white Connecticut residents diagnosed with colorectal cancer in 1994-1999 were identified from the population-based statewide Connecticut cancer registry. Comorbid DM was defined as an inpatient hospital admission (prior to or around the time of colorectal cancer diagnosis) that included DM as one of up to 10 discharge diagnoses.
Comorbid DM, identified for 1014 (10.8%) of the 9395 patients, was associated with a statistically significantly elevated risk of death from any cause (hazard ratio or HR=1.38, 95% confidence interval 1.27-1.49), in a proportional hazards regression model that included age, sex, race and extent of disease at diagnosis. This finding was due to an elevated risk of death from causes of death other than colorectal cancer.
Studies are needed on quality of care for comorbid DM and its complications among colorectal cancer patients.
少数研究探讨了糖尿病（DM）合并症与结直肠癌诊断后生存率之间的关联，但纳入的糖尿病患者数量较少，且未对死因进行研究。
从基于人群的康涅狄格州全州癌症登记处识别出1994 - 1999年期间诊断为结直肠癌的所有542名非裔美国人（黑人）和8853名白人康涅狄格州居民。合并DM定义为（在结直肠癌诊断之前或之时）住院治疗，其中DM作为多达10项出院诊断之一。
在9395名患者中，有1014名（10.8%）被确定患有合并DM，在包含年龄、性别、种族和诊断时疾病范围的比例风险回归模型中，合并DM与任何原因导致的死亡风险在统计学上显著升高相关（风险比或HR = 1.38，95%置信区间1.27 - 1.49）。这一发现是由于结直肠癌以外的死因导致的死亡风险升高。
需要对结直肠癌患者合并DM及其并发症的护理质量进行研究。
