Sillesen H, Madelung S, Eldrup N, Roed M
Department of Vascular Surgery, Rigshospitalet, Denmark.
Eur J Vasc Endovasc Surg. 2007 Jan;33(1):26-32. doi: 10.1016/j.ejvs.2006.07.022. Epub 2006 Oct 25.
Patients with PAD may have severe symptoms from their lower extremities as well as a 3-4 fold increased risk of death due to systemic atherosclerosis. The purpose of this study was to identify whether treatment goals of a nurse led rehabilitation clinic were achieved.
Prospective cohort study over 4 year period to May 2004.
All patients with symptomatic PAD were offered enrollment in a nurse-led rehabilitation clinic and given advice on diet and exercise. All smokers were offered smoking cessation advice and treatment. Anti-platelet therapy was prescribed to all patients and statin therapy was prescribed to those with dyslipidemia.
693 patients with symptomatic PAD were prospectively entered into the clinic (total 2563 clinic visits). Average age was 67 years and 53% were males. Some (167, 24%) were included for non-surgical treatment and most (526, 76%) were included as part of their postoperative follow-up. After 6 months, the proportion of patients taking platelet inhibitors and statins had increased from 63% and 27% to 87% and 84% respectively. Mean total cholesterol was reduced from 6.2 mmol/l to 4.9 mmol/l and mean LDL cholesterol from 3.9 mmol/l to 2.6 mmol/l. After 1 year the proportion of smokers was reduced from 59% to 51.5% (12.5% relative reduction).
This nurse-driven rehabilitation clinic has proven effective in reaching medication targets for secondary prevention. Smoking cessation was less successful.
外周动脉疾病(PAD)患者可能下肢出现严重症状,且因全身性动脉粥样硬化导致的死亡风险增加3至4倍。本研究的目的是确定由护士主导的康复诊所的治疗目标是否达成。
至2004年5月为期4年的前瞻性队列研究。
所有有症状的PAD患者均受邀参加由护士主导的康复诊所,并接受饮食和运动方面的建议。所有吸烟者均获提供戒烟建议和治疗。所有患者均接受抗血小板治疗,血脂异常者接受他汀类药物治疗。
693例有症状的PAD患者前瞻性纳入该诊所(共就诊2563次)。平均年龄67岁,53%为男性。部分患者(167例,24%)纳入非手术治疗,多数患者(526例,76%)纳入术后随访。6个月后,服用血小板抑制剂和他汀类药物的患者比例分别从63%和27%增至87%和84%。总胆固醇均值从6.2 mmol/L降至4.9 mmol/L,低密度脂蛋白胆固醇均值从3.9 mmol/L降至2.6 mmol/L。1年后,吸烟者比例从59%降至51.5%(相对降低12.5%)。
该由护士主导的康复诊所在实现二级预防用药目标方面已证明有效。戒烟成效较差。