Pakarinen Satu, Takegata Rika, Rinne Teemu, Huotilainen Minna, Näätänen Risto
Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, P.O. Box 9, FIN-00014, Finland.
Clin Neurophysiol. 2007 Jan;118(1):177-85. doi: 10.1016/j.clinph.2006.09.001. Epub 2006 Oct 27.
Mismatch negativity (MMN), a change-specific component of the auditory event-related potential (ERP), is sensitive to deficits in central auditory processing associated with many clinical conditions. The aim of this study was to obtain a comprehensive multi-dimensional profile of central auditory processing by extending the recently developed fast multi-feature MMN paradigm [Näätänen R, Pakarinen S, Rinne T, Takegata R. The mismatch negativity (MMN): towards the optimal paradigm. Clin Neurophysiol 2004;115:140-144].
MMN responses to changes in sound duration, frequency, intensity, and perceived sound-source location at six different magnitudes of deviation were recorded from healthy young adults by using the multi-feature MMN paradigm. In addition, behavioural discrimination accuracy and speed were measured to examine the relationship between MMN and behavioural performance.
All the 24 sound changes elicited significant MMNs. MMN amplitude increased and latency decreased with increasing magnitude of sound change. Furthermore, the MMN amplitude and latency predicted the subjects' accuracy and speed in detecting these deviations.
This new paradigm provides an extensive auditory discrimination profile for several auditory attributes at different deviation magnitudes in a minimal recording time.
The auditory discrimination profiles can offer a comprehensive view of the development, plasticity, and deficits of central auditory processing.
失匹配负波（MMN）是听觉事件相关电位（ERP）的一种特定于变化的成分，对与许多临床状况相关的中枢听觉处理缺陷敏感。本研究的目的是通过扩展最近开发的快速多特征MMN范式[纳塔南R、帕卡里宁S、林内T、武形R。失匹配负波（MMN）：迈向最佳范式。临床神经生理学2004；115：140 - 144]来获得中枢听觉处理的全面多维概况。
使用多特征MMN范式，记录健康年轻成年人对声音持续时间、频率、强度以及感知声源位置在六种不同偏差幅度下变化的MMN反应。此外，测量行为辨别准确性和速度以检验MMN与行为表现之间的关系。
所有24种声音变化均引发了显著的MMN。随着声音变化幅度的增加，MMN波幅增大，潜伏期缩短。此外，MMN波幅和潜伏期预测了受试者检测这些偏差的准确性和速度。
这种新范式在最短记录时间内为不同偏差幅度下的几种听觉属性提供了广泛的听觉辨别概况。
听觉辨别概况可以提供关于中枢听觉处理的发育、可塑性和缺陷的全面视图。
