Fierlbeck G, Breuninger H, Fierlbeck B, Rassner G
Hautklinik, Universität Tübingen.
Hautarzt. 1991 Jan;42(1):39-43.
An open study was carried out to test the effect of systemic administration of interferon (IFN) gamma and local application of IFN beta as monotherapy and adjuvant treatment. The topical application of IFN beta gel had no effect as monotherapy and when it was given as adjuvant therapy the rate of recurrence was not significantly reduced. IFN gamma was given for monotherapy in two different doses (100 and 200 micrograms per s.c. injection). The response rate to the cyclic treatment was 45% in the group (20 patients) receiving a dosage of 100 micrograms, and 57% in the group (26 patients) receiving a dosage of 200 micrograms. Patients with a duration of the disease longer than 18 months and patients with immune deficiency did not respond to the monotherapy. A group of 15 patients with resistant genital warts received adjuvant treatment with IFN gamma over 7 days after surgical treatment. In patients with inconspicuous immune status it was possible to reduce the recurrence rate.
开展了一项开放性研究，以测试全身给予γ干扰素以及局部应用β干扰素作为单一疗法和辅助治疗的效果。β干扰素凝胶的局部应用作为单一疗法无效，作为辅助治疗时复发率也未显著降低。γ干扰素以两种不同剂量（每次皮下注射100和200微克）用于单一疗法。接受100微克剂量的组（20例患者）对循环治疗的有效率为45%，接受200微克剂量的组（26例患者）为57%。病程超过18个月的患者和免疫缺陷患者对单一疗法无反应。一组15例难治性尖锐湿疣患者在手术治疗后接受了7天的γ干扰素辅助治疗。在免疫状态不明显的患者中，可以降低复发率。
