Choi Jeeyoung, Bodugoz-Senturk Hatice, Kung Hsiang J, Malhi Arnaz S, Muratoglu Orhun K
Department of Orthopaedic Surgery, Harris Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA.
Biomaterials. 2007 Feb;28(5):772-80. doi: 10.1016/j.biomaterials.2006.09.049. Epub 2006 Oct 27.
As a synthetic replacement material for osteochondral defect repair, poly(vinyl alcohol) (PVA) hydrogels offer a great potential due to their high water content and strong mechanical integrity. To survive the high stress environment in the joint space, high creep resistance becomes one of the key requirements for hydrogel implants. We hypothesized that reducing the equilibrium water content (EWC) of hydrogels would improve their creep resistance. We investigated the effect of dehydration of PVA theta-gels in various solvent/solution media followed by rehydration in saline solution. Decreasing EWC increased the creep resistance of PVA theta-gels. The most effective medium was isopropyl alcohol for reducing the EWC and increasing the creep resistance of PVA theta-gels.
作为用于骨软骨缺损修复的合成替代材料，聚乙烯醇（PVA）水凝胶因其高含水量和强大的机械完整性而具有巨大潜力。为了在关节空间的高应力环境中存活，高抗蠕变性成为水凝胶植入物的关键要求之一。我们假设降低水凝胶的平衡含水量（EWC）会提高其抗蠕变性。我们研究了PVA θ-凝胶在各种溶剂/溶液介质中脱水后再在盐溶液中再水化的效果。降低EWC可提高PVA θ-凝胶的抗蠕变性。最有效的介质是异丙醇，它能降低PVA θ-凝胶的EWC并提高其抗蠕变性。
