Bowden Nikola A, Scott Rodney J, Tooney Paul A
Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia.
Schizophr Res. 2007 Jan;89(1-3):165-8. doi: 10.1016/j.schres.2006.09.003. Epub 2006 Oct 30.
To identify altered mRNA expression of regulator of G-protein signalling 4 (RGS4) in the superior temporal gyrus (STG) in schizophrenia mRNA expression of RGS4 was measured from post-mortem STG tissue from 13 individuals with schizophrenia and 13 matched non-psychiatric controls using relative real-time PCR. Significantly decreased expression of RGS4 mRNA in the STG in schizophrenia was identified in 10 of the 13 matched pairs. Altered expression of RGS4 in cortical regions previously implicated in schizophrenia, such as the STG further supports the notion of RGS4 as a potential genetic and functional biological marker of schizophrenia.
为了鉴定精神分裂症患者颞上回（STG）中G蛋白信号调节因子4（RGS4）的mRNA表达变化，我们使用相对实时PCR从13例精神分裂症患者和13例匹配的非精神疾病对照的死后STG组织中测量了RGS4的mRNA表达。在13对匹配样本中，有10对发现精神分裂症患者的STG中RGS4 mRNA表达显著降低。RGS4在先前与精神分裂症相关的皮质区域（如STG）中的表达改变，进一步支持了RGS4作为精神分裂症潜在遗传和功能生物学标志物的观点。
Zotero 插件