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耳霉菌病:临床特征及治疗要点

Otomycosis: clinical features and treatment implications.

作者信息

Ho Tang, Vrabec Jeffrey T, Yoo Donald, Coker Newton J

机构信息

Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.

出版信息

Otolaryngol Head Neck Surg. 2006 Nov;135(5):787-91. doi: 10.1016/j.otohns.2006.07.008.

Abstract

OBJECTIVES

To determine the clinical presentation, predisposing factors, complications, and treatment outcomes of otomycosis.

STUDY DESIGN AND SETTING

Retrospective review of 132 patients with a clinical diagnosis of otomycosis treated from 1998 to 2004 in an academic otology practice.

RESULTS

Otalgia and otorrhea were the most common presenting complaints (48%). Prior otologic procedures increase the risk of developing otomycosis. Residual disease was observed in 13% and recurrence in 15% of the subjects. The presence of a mastoid cavity was associated with higher recurrent and residual disease rates. Topical ketoconazole, cresylate otic drops, and aluminum acetate otic drops were all relatively effective with >80% resolution rate on initial application, although topical ketoconazole had a higher resolution rate and lower rate of disease recurrence.

CONCLUSIONS AND SIGNIFICANCE

Otomycosis can usually be diagnosed by clinical examination and often occurs in the setting of persistent otorrhea. Complications are not uncommon but usually resolve with application of appropriate topical antifungal agents. Eradication of disease is more difficult in the presence of a mastoid cavity.

摘要

目的

确定外耳道真菌病的临床表现、诱发因素、并发症及治疗效果。

研究设计与背景

对1998年至2004年在一家学术性耳科诊所临床诊断为外耳道真菌病的132例患者进行回顾性研究。

结果

耳痛和耳漏是最常见的主诉(48%)。既往耳科手术会增加患外耳道真菌病的风险。13%的受试者观察到残留疾病,15%复发。乳突腔的存在与较高的复发率和残留疾病率相关。局部使用酮康唑、甲酚耳滴剂和醋酸铝耳滴剂均相对有效,初次使用时治愈率>80%,尽管局部使用酮康唑治愈率更高且疾病复发率更低。

结论与意义

外耳道真菌病通常可通过临床检查诊断,且常发生于持续性耳漏的情况下。并发症并不少见,但通常通过应用适当的局部抗真菌药物得以解决。在存在乳突腔的情况下,疾病根除更为困难。

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