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肺泡软组织肉瘤:综述与更新

Alveolar soft-part sarcoma: a review and update.

作者信息

Folpe A L, Deyrup A T

机构信息

Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Minnesota, USA.

出版信息

J Clin Pathol. 2006 Nov;59(11):1127-32. doi: 10.1136/jcp.2005.031120.

Abstract

Alveolar soft-part sarcoma (ASPS) is a rare, distinctive sarcoma, typically occurring in young patients. Although it displays a relatively indolent clinical course, the ultimate prognosis is poor and is often characterised by late metastases. Recently, our understanding of the genetic events underlying the pathogenesis of ASPS has greatly increased. The historical, histopathological, ultrastructural, immunohistochemical and genetic aspects of ASPS are reviewed in this article.

摘要

肺泡软组织肉瘤(ASPS)是一种罕见的、独特的肉瘤,通常发生于年轻患者。尽管其临床病程相对惰性,但最终预后较差,且常以晚期转移为特征。最近,我们对ASPS发病机制背后的基因事件的理解有了很大提高。本文对ASPS的历史、组织病理学、超微结构、免疫组织化学和遗传学方面进行了综述。

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