Rival A-L, Allombert-Blaise C, Ly A, Grandjean J-P, Faure M, Claudy A
Service de Dermatologie, Hôpital Edouard Herriot, place d'Arsonval, 69437 Lyon Cedex 03.
Ann Dermatol Venereol. 2006 Oct;133(10):781-3. doi: 10.1016/s0151-9638(06)71043-2.
Nicorandil is a potassium-channel activator used in the treatment of angina pectoris. The first cases of anal ulcerations induced by nicorandil were published in 2002.
A 71-year-old man presented with a 2-year history of anal ulcerations occurring within a few months of initiation of treatment with Nicorandil. Histological tests on a biopsy sample showed granulation tissue with non-specific chronic inflammation. Nicorandil was stopped and this resulted in complete healing of the ulcers after three months.
Nicorandil can induce chronic and extensive anal ulcerations. The pathogenesis is unknown. Patients are usually treated with high doses of nicorandil. Dermatologists should be aware of this rare side-effect which heals after withdrawal of the drug.
尼可地尔是一种用于治疗心绞痛的钾通道激活剂。2002年首次报道了尼可地尔引起的肛门溃疡病例。
一名71岁男性，在开始使用尼可地尔治疗后的几个月内出现了为期2年的肛门溃疡病史。对活检样本进行的组织学检查显示为伴有非特异性慢性炎症的肉芽组织。停用尼可地尔，三个月后溃疡完全愈合。
尼可地尔可诱发慢性广泛性肛门溃疡。其发病机制尚不清楚。患者通常接受高剂量的尼可地尔治疗。皮肤科医生应意识到这种罕见的副作用，停药后可治愈。
