Hammam T, Montgomery D, Morris D, Imrie F
Glasgow Royal Infirmary, Alexandra Parade, Glasgow, UK. thammamaol.com
Eye (Lond). 2008 Mar;22(3):349-53. doi: 10.1038/sj.eye.6702613. Epub 2006 Oct 27.
To investigate the possible link between normal tension glaucoma (NTG) and autoimmunity.
We studied the serum of 95 patients: 31 with NTG, 32 with primary open-angle glaucoma (POAG), and 32 age- and sex-matched controls. Blood was drawn from each patient and serum was examined for the presence of antinuclear antigens (ANA), autoantibodies to extractable nuclear antigens (ENA), anti-double-strand DNA, serum protein electrophoresis, and immunoglobulin (IgG, IgA, and IgM) levels.
In the NTG group, the relative risks for ANA and ENA positivity were 2.5 and 4.4 times, respectively, that of the control group. There was a statistically significant difference between IgA levels in the NTG and control group (P=0.024), but there was no statistically significant difference between both groups regarding IgM or IgG levels. In the POAG group, the relative risks for ANA and ENA positivity were 0.77 and 2.9 times, respectively, that of the control group. The relative risk for detection of paraprotein in the POAG group was 0.97 times that of the control group. Also, there was a statistically significant difference between IgA levels in the POAG and control group (P=0.011), but there was no statistically significant difference between both groups regarding IgM or IgG.
These results support the hypothesis that humoral immune mechanisms may have a role in the pathogenesis of NTG.
研究正常眼压性青光眼（NTG）与自身免疫之间可能存在的联系。
我们研究了95例患者的血清：31例NTG患者、32例原发性开角型青光眼（POAG）患者以及32例年龄和性别匹配的对照组。从每位患者采集血液，检测血清中抗核抗原（ANA）、可提取核抗原自身抗体（ENA）、抗双链DNA、血清蛋白电泳以及免疫球蛋白（IgG、IgA和IgM）水平。
在NTG组中，ANA和ENA阳性的相对风险分别是对照组的2.5倍和4.4倍。NTG组与对照组的IgA水平存在统计学显著差异（P = 0.024），但两组在IgM或IgG水平方面无统计学显著差异。在POAG组中，ANA和ENA阳性的相对风险分别是对照组的0.77倍和2.9倍。POAG组检测到副蛋白的相对风险是对照组的0.97倍。此外，POAG组与对照组的IgA水平存在统计学显著差异（P = 0.011），但两组在IgM或IgG方面无统计学显著差异。
这些结果支持体液免疫机制可能在NTG发病机制中起作用这一假说。
