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Contribution of consanguinuity to polygenic and multifactorial diseases.

作者信息

Rudan Igor, Campbell Harry, Carothers Andrew D, Hastie Nicholas D, Wright Alan F

出版信息

Nat Genet. 2006 Nov;38(11):1224-5. doi: 10.1038/ng1106-1224.

DOI:10.1038/ng1106-1224

PMID:17072294

Abstract

摘要

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Contribution of consanguinuity to polygenic and multifactorial diseases.

作者信息

Rudan Igor, Campbell Harry, Carothers Andrew D, Hastie Nicholas D, Wright Alan F

出版信息

Nat Genet. 2006 Nov;38(11):1224-5. doi: 10.1038/ng1106-1224.

DOI:10.1038/ng1106-1224

PMID:17072294

Abstract

摘要

相似文献

Contribution of consanguinuity to polygenic and multifactorial diseases.

Nat Genet. 2006 Nov;38(11):1224-5. doi: 10.1038/ng1106-1224.

Consanguinity: implications for practice, research, and policy.

Lancet. 2006 Mar 25;367(9515):970-1. doi: 10.1016/S0140-6736(06)68406-7.

New Framework Developed for Polygenic Risk Score Reporting.

Am J Med Genet A. 2021 Jun;185(6):1645-1646. doi: 10.1002/ajmg.a.61675.

Genetic diseases in Arab populations.

East Mediterr Health J. 1999 Nov;5(6):1102-3.

Genome-wide association studies (GWAS) in complex diseases: advantages and limitations.

Reumatol Clin. 2012 Mar-Apr;8(2):56-7. doi: 10.1016/j.reuma.2011.07.005. Epub 2011 Nov 15.

Mathematical model for polygenic diseases.

Med Hypotheses. 2005;64(6):1240-1. doi: 10.1016/j.mehy.2005.01.008.

Opening Pandora's box: clinical data and the study of complex diseases.

Sci STKE. 2002 Apr 30;2002(130):pe20. doi: 10.1126/stke.2002.130.pe20.

Why are polygenic hereditary diseases so difficult to investigate? An exercise of theoretical enzymology.

Ital J Biochem. 2005 Sep-Dec;54(3-4):229-31.

Proprietary Algorithms for Polygenic Risk: Protecting Scientific Innovation or Hiding the Lack of It?

Genes (Basel). 2019 Jun 13;10(6):448. doi: 10.3390/genes10060448.

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Trends Mol Med. 2001 Nov;7(11):512-6. doi: 10.1016/s1471-4914(01)02163-3.

引用本文的文献

variants beyond type 1 and type 2 diabetes: exploring clinical diversity and epigenetic associations in Arab cohorts.

Front Genet. 2023 Oct 24;14:1254833. doi: 10.3389/fgene.2023.1254833. eCollection 2023.

Features of chromosomal abnormalities in relation to consanguinity: analysis of 10,556 blastocysts from IVF/ICSI cycles with PGT-A from consanguineous and non-consanguineous couples.

Sci Rep. 2023 May 31;13(1):8857. doi: 10.1038/s41598-023-36014-6.

Inbreeding, Native American ancestry and child mortality: linking human selection and paediatric medicine.

Hum Mol Genet. 2022 Mar 21;31(6):975-984. doi: 10.1093/hmg/ddab302.

Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population.

Hum Genet. 2021 Mar;140(3):505-528. doi: 10.1007/s00439-020-02222-7. Epub 2020 Sep 9.

Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population.

Sci Rep. 2020 Jan 13;10(1):152. doi: 10.1038/s41598-019-57072-9.

Genomic Patterns of Homozygosity in Chinese Local Cattle.

Sci Rep. 2019 Nov 18;9(1):16977. doi: 10.1038/s41598-019-53274-3.

Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population.

J Lipid Res. 2018 Oct;59(10):1951-1966. doi: 10.1194/jlr.P080218. Epub 2018 Aug 14.

Consanguineous Marriage and the Psychopathology of Progeny: A Population-wide Data Linkage Study.

JAMA Psychiatry. 2018 May 1;75(5):438-446. doi: 10.1001/jamapsychiatry.2018.0133.

Runs of homozygosity: windows into population history and trait architecture.

Nat Rev Genet. 2018 Apr;19(4):220-234. doi: 10.1038/nrg.2017.109. Epub 2018 Jan 15.

Consanguinity, endogamy, and genetic disorders in Tunisia.

J Community Genet. 2013 Apr;4(2):273-84. doi: 10.1007/s12687-012-0128-7. Epub 2012 Dec 4.