胆囊充盈激素基础的鉴定。

Identification of a hormonal basis for gallbladder filling.

作者信息

Choi Mihwa, Moschetta Antonio, Bookout Angie L, Peng Li, Umetani Michihisa, Holmstrom Sam R, Suino-Powell Kelly, Xu H Eric, Richardson James A, Gerard Robert D, Mangelsdorf David J, Kliewer Steven A

机构信息

Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

出版信息

Nat Med. 2006 Nov;12(11):1253-5. doi: 10.1038/nm1501. Epub 2006 Oct 29.

DOI:10.1038/nm1501

PMID:17072310

Abstract

The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility.

摘要

胆囊的充盈和排空周期控制着胆汁流入肠道以进行消化。我们在此表明，成纤维细胞生长因子-15是一种由远端小肠在胆汁酸作用下产生的激素，它是胆囊充盈所必需的。这些研究表明，胆囊充盈是由一条内分泌途径积极调控的，并提示了一种控制胆囊运动的餐后定时机制。