Suzaki Noriyuki, Hiraki Akio, Takigawa Nagio, Ueoka Hiroshi, Tanimoto Yasushi, Kozuki Toshiyuki, Tabata Masahiro, Kanehiro Arihiko, Kiura Katsuyuki, Tanimoto Mitsune
Department of Respiratory Medicine, Okayama University Hospital, Okayama 700-8558, Japan.
Acta Med Okayama. 2006 Oct;60(5):295-8. doi: 10.18926/AMO/30737.
A 71-year-old Japanese man with adenocarcinoma of the lung developed interstitial pneumonia after treatment with paclitaxel. The patient had acute chills and fever on the fourth day after the second exposure to paclitaxel, rapidly got worse despite empiric therapies, and developed prolonged respiratory failure requiring mechanical ventilation. Four months later, he died of respiratory failure due to progression of both interstitial pneumonia and lung cancer. This is the first case developing fatal paclitaxel-induced pulmonary toxicity to date. Interstitial pneumonia should be considered one of the possible life-threatening complications during treatment with paclitaxel.
一名71岁的日本男性肺癌腺癌患者在接受紫杉醇治疗后发生间质性肺炎。该患者在第二次接触紫杉醇后的第四天出现急性寒战和发热，尽管进行了经验性治疗，但病情迅速恶化，并发展为需要机械通气的长期呼吸衰竭。四个月后，他因间质性肺炎和肺癌进展导致呼吸衰竭死亡。这是迄今为止首例发生致命性紫杉醇诱导的肺毒性的病例。在紫杉醇治疗期间，应将间质性肺炎视为可能危及生命的并发症之一。
