Harraghy Niamh, Kerdudou Sylvain, Herrmann Mathias
Institute of Medical Microbiology and Hygiene, Saarland University Hospital, Building 43, 66421, Homburg/Saar, Germany.
Anal Bioanal Chem. 2007 Jan;387(2):437-44. doi: 10.1007/s00216-006-0860-0. Epub 2006 Oct 28.
The staphylococci are an ever-present threat in our world, capable of causing a wide range of infections, and are a persistent presence in the clinical environment. As the number of antimicrobial compounds effective against staphylococci decreases, because of the acquisition and spread of antibiotic resistance, there is a growing need for novel therapeutic molecules. Intra and inter-species communication (quorum sensing) is a biologically significant phenomenon that has been associated with virulence, intracellular survival, and biofilm formation. Quorum sensing molecules of staphylococci and other species (e.g. Pseudomonas aeruginosa) can inhibit virulence factor production and/or growth of staphylococci, leading to the possibility that interference with staphylococcal quorum-sensing systems could be a way of controlling the diverse infections caused by the staphylococci. In this article, we discuss the potential of quorum-sensing systems of staphylococci as therapeutic targets.
葡萄球菌在我们的世界中始终构成威胁，能够引发多种感染，且在临床环境中持续存在。由于抗生素耐药性的获得与传播，有效对抗葡萄球菌的抗菌化合物数量不断减少，因此对新型治疗分子的需求日益增长。种内和种间通讯（群体感应）是一种具有生物学意义的现象，与毒力、细胞内存活及生物膜形成相关。葡萄球菌及其他物种（如铜绿假单胞菌）的群体感应分子可抑制葡萄球菌毒力因子的产生和/或生长，这使得干扰葡萄球菌群体感应系统有可能成为控制由葡萄球菌引起的各种感染的一种方法。在本文中，我们讨论了葡萄球菌群体感应系统作为治疗靶点的潜力。
