Studer Sean M, Orens Jonathan B
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Semin Respir Crit Care Med. 2006 Oct;27(5):492-500. doi: 10.1055/s-2006-954607.
While there is little doubt that proper donor selection is extremely important to achieve good outcomes from transplantation, there are only limited data regarding the current criteria utilized to select the "ideal donor". Importantly, there are not enough donor lungs available for all of those in need. Until an adequate supply of donor organs exists, lives will be lost on the transplant waiting list. While efforts have been made to increase donor awareness, additional transplants can be realized by improving donor utilization. This can be achieved by active participation of transplant teams in donor management and by utilizing "extended criteria" organs. Further studies are needed to assess the impact of using "extended criteria" donors, as this practice could result in increased posttransplant morbidity and mortality. This article summarizes the approach to identification of potential lung donors, optimal donor management, and the clinical importance of various donor factors upon recipient outcomes.
虽然毫无疑问，合适的供体选择对于实现移植的良好效果极为重要，但关于目前用于选择“理想供体”的标准的数据有限。重要的是，没有足够的供体肺可供所有有需要的人使用。在有足够的供体器官供应之前，移植等待名单上的患者将会死亡。虽然已经努力提高对供体的认识，但通过改善供体利用可以实现更多的移植。这可以通过移植团队积极参与供体管理以及利用“扩大标准”器官来实现。需要进一步研究来评估使用“扩大标准”供体的影响，因为这种做法可能会导致移植后发病率和死亡率增加。本文总结了识别潜在肺供体的方法、最佳供体管理以及各种供体因素对受体结局的临床重要性。
