Hadjiliadis Denis, Angel Luis F
Division of Allergy, Pulmonary, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Semin Respir Crit Care Med. 2006 Oct;27(5):561-6. doi: 10.1055/s-2006-954613.
Lung transplantation is commonly used for patients with end-stage lung disease. However, there is continuing debate on the optimal operation for patients with chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. Single-lung transplantation (SLT) provides equivalent short- and medium-term results compared with bilateral lung transplantation (BLT), but long-term survival appears slightly better in BLT recipients (especially in patients with COPD). The number of available organs for lung transplantation also influences the choice of operation. Recent developments suggest that the organ donor shortage is not as severe as previously thought, making BLT a possible alternative for more patients. Local expertise and waiting list issues are important in influencing the choice of SLT versus BLT. Most of the data support the use of BLT for the majority of COPD patients when available, and the use of SLT for the majority of idiopathic pulmonary fibrosis (IPF) patients. The ultimate choice of operation will depend on donor and recipient characteristics and local expertise and waiting list issues.
肺移植常用于终末期肺病患者。然而，对于慢性阻塞性肺疾病（COPD）和肺纤维化患者的最佳手术方式仍存在持续的争论。与双肺移植（BLT）相比，单肺移植（SLT）在短期和中期效果相当，但BLT受者的长期生存率似乎略高（尤其是COPD患者）。可用于肺移植的器官数量也会影响手术方式的选择。最近的进展表明，器官供体短缺并不像之前认为的那么严重，这使得BLT成为更多患者的一种可能选择。当地的专业技术和等待名单问题在影响SLT与BLT的选择上很重要。大多数数据支持在有条件时，大多数COPD患者采用BLT，大多数特发性肺纤维化（IPF）患者采用SLT。最终的手术选择将取决于供体和受体的特征、当地的专业技术以及等待名单问题。
