García Patricia, Tajadura Virginia, García Ignacio, Sánchez Yolanda
Instituto de Microbiología Bioquímica, CSIC/Universidad de Salamanca and Departamento de Microbiología y Genética, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
Yeast. 2006 Oct 15;23(13):1031-43. doi: 10.1002/yea.1409.
The Rho family of GTPases are highly conserved molecular switches that control some of the most fundamental processes of cell biology, including morphogenesis, vesicular transport, cell division and motility. Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to extracellular stimuli. In fission yeast, there are seven Dbl-related GEFs and they activate six Rho-type GTPases within a particular spatio-temporal context. The failure to do so might have consequences reflected in aberrant phenotypes and in some cases lead to cell death. In this review, we briefly summarize the role of Rho GTPases and Rho-GEFs in the establishment and maintenance of cell polarity and cell integrity in Schizosaccharomyces pombe.
Rho家族的GTP酶是高度保守的分子开关，控制细胞生物学中一些最基本的过程，包括形态发生、囊泡运输、细胞分裂和运动。鸟嘌呤核苷酸交换因子（GEFs）直接负责响应细胞外刺激激活Rho家族的GTP酶。在裂殖酵母中，有七个与Dbl相关的GEFs，它们在特定的时空背景下激活六种Rho型GTP酶。若无法做到这一点，可能会导致异常表型，并在某些情况下导致细胞死亡。在本综述中，我们简要总结了Rho GTP酶和Rho-GEFs在粟酒裂殖酵母细胞极性建立和维持以及细胞完整性方面的作用。
