人类肝脏肿瘤发生中的肝祖细胞
Hepatic progenitor cells in human liver tumor development.
作者信息
Libbrecht Louis
机构信息
Laboratory of Morphology and Molecular Pathology, Minderbroedersstraat 12, Leuven 3000, Belgium.
出版信息
World J Gastroenterol. 2006 Oct 21;12(39):6261-5. doi: 10.3748/wjg.v12.i39.6261.
Abstract
In recent years, the results of several studies suggest that human liver tumors can be derived from hepatic progenitor cells rather than from mature cell types. The available data indeed strongly suggest that most combined hepatocellular-cholangiocarcinomas arise from hepatic progenitor cells that retained their potential to differentiate into the hepatocytic and biliary lineages. Hepatic progenitor cells could also be the basis for some hepatocellular carcinomas and hepatocellular adenomas, although it is very difficult to determine the origin of an individual hepatocellular carcinoma. There is currently not enough data to make statements regarding a hepatic progenitor cell origin of cholangiocarcinoma. The presence of hepatic progenitor cell markers and the presence and extent of the cholangiocellular component are factors that are related to the prognosis of hepatocellular carcinomas and combined hepatocellular-cholangiocarcinomas, respectively.
摘要
近年来，多项研究结果表明，人类肝脏肿瘤可能源自肝祖细胞，而非成熟细胞类型。现有数据确实有力地表明，大多数肝细胞胆管癌源自保留了向肝细胞和胆管谱系分化潜能的肝祖细胞。肝祖细胞也可能是某些肝细胞癌和肝细胞腺瘤的基础，尽管很难确定单个肝细胞癌的起源。目前尚无足够数据来阐述胆管癌的肝祖细胞起源。肝祖细胞标志物的存在以及胆管细胞成分的存在和程度分别是与肝细胞癌和肝细胞胆管癌预后相关的因素。
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