胃癌的p53基因多态性：早期胃癌与进展期胃癌的差异
A p53 genetic polymorphism of gastric cancer: difference between early gastric cancer and advanced gastric cancer.
作者信息
Yi Sun Young, Lee Woon Jung
机构信息
Department of Internal Medicine and Medical Research Center, College of Medicine, Ewha Womans University, Seoul, Korea.
出版信息
World J Gastroenterol. 2006 Oct 28;12(40):6536-9. doi: 10.3748/wjg.v12.i40.6536.
AIM
To investigate the role of the polymorphism of p53 codon 72 in early gastric cancer (EGC) and advanced gastric cancer (AGC) in Korean patients.
METHODS
DNA was extracted from blood samples of gastric cancer patients (n=291) and controls (n=216). In the p53 codon 72 genotypes were determined by PCR-RFLP.
RESULTS
Patients with gastric cancer had a significantly higher frequency of the homozygous proline (Pro) allele than the control (P=0.032). Patients with AGC had a significantly higher frequency of the Arg/Arg (arginine) allele (P=0.038) than EGC and a similar Pro/Pro allele. The signet ring cell type had a higher frequency of the Pro/Pro allele than other types (P=0.031). The Pro/Pro genotype carries a 3.9-fold increased risk of developing gastric cancer (95% CI, 1.3-15.4, P=0.039) when compared to Arg/Arg and Arg/Pro genotypes and to develop EGC is a 5.25 fold increased risk (95% CI, 1.8-19.6, P=0.021).
CONCLUSION
The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk for EGC than AGC.
目的
研究p53密码子72多态性在韩国早期胃癌（EGC）和进展期胃癌（AGC）患者中的作用。
方法
从胃癌患者（n = 291）和对照组（n = 216）的血液样本中提取DNA。通过PCR-RFLP确定p53密码子72的基因型。
结果
胃癌患者中纯合脯氨酸（Pro）等位基因的频率显著高于对照组（P = 0.032）。AGC患者中Arg/Arg（精氨酸）等位基因的频率（P = 0.038）显著高于EGC患者，且Pro/Pro等位基因频率相似。印戒细胞型Pro/Pro等位基因的频率高于其他类型（P = 0.031）。与Arg/Arg和Arg/Pro基因型相比，Pro/Pro基因型患胃癌的风险增加3.9倍（95%CI，1.3 - 15.4，P = 0.039），患EGC的风险增加5.25倍（95%CI，1.8 - 19.6，P = 0.021）。
结论
p53密码子72多态性的Pro/Pro基因型总体上患胃癌的风险更高，且与EGC的风险关联程度远高于AGC。
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