Pertsov S S
P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2006 Mar;141(3):292-5. doi: 10.1007/s10517-006-0153-9.
We studied the effects of acute stress and exogenous melatonin on stress marker organs in rats. Administration of melatonin under normal conditions increased the relative weights of the thymus (active rats) and adrenal glands (active and passive rats). The relative weight of the spleen also tended to increase after melatonin treatment. Stress led to involution of the thymus and hypertrophy of the adrenal glands in active and especially in passive animals receiving physiological saline. Melatonin partially or completely prevented involution of the thymus under stress conditions. Stress had no effect on the relative weight of the adrenal glands in melatonin-treated rats. The relative weight of the spleen in active rats receiving melatonin in doses of 0.5 and 1 mg/kg decreased after stress exposure. Our results suggest that melatonin modulates the hemodynamics and function of stress marker organs.
我们研究了急性应激和外源性褪黑素对大鼠应激标记器官的影响。在正常条件下给予褪黑素可增加胸腺（活跃大鼠）和肾上腺（活跃和被动大鼠）的相对重量。褪黑素处理后脾脏的相对重量也有增加的趋势。应激导致活跃动物尤其是接受生理盐水的被动动物的胸腺萎缩和肾上腺肥大。褪黑素在应激条件下部分或完全预防了胸腺萎缩。应激对接受褪黑素处理的大鼠肾上腺的相对重量没有影响。接受0.5和1mg/kg剂量褪黑素的活跃大鼠在应激暴露后脾脏的相对重量下降。我们的结果表明，褪黑素可调节应激标记器官的血流动力学和功能。
